It is very meaningful to make use of Metasequoia glyptostroboides to produce high quality structural board. It helps not only to solve problem of how to use Metasequoia glyptostroboides efficiently and reasonably,but also to alleviate contradiction between supply and demand of structural board. In this study, wood properties of Metasequoia glyptostroboides relating to manufacturing technology of OSB were analyzed, The OSB was made and its properties were measured in laboratory. The results showed that manufacturing OSB of Metasequoia glyptostroboides with UF resin was successful. The board properties can reach or excess European standard EN300 when appropriate technology was applied.